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Chandra Bartholomeusz Selected Research

Neoplasms (Cancer)

1/2021Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway-Dependent Apoptosis.
1/2020Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin.
1/2020Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer.
6/2019Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer.
1/2019A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation.
6/2017IKK inhibition by BMS-345541 suppresses breast tumorigenesis and metastases by targeting GD2+ cancer stem cells.
1/2017MELK: a potential novel therapeutic target for TNBC and other aggressive malignancies.
12/2015Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.
12/2015MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model.
3/2015HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.
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Chandra Bartholomeusz Research Topics

Disease

23Neoplasms (Cancer)
01/2021 - 11/2002
20Breast Neoplasms (Breast Cancer)
09/2021 - 01/2007
11Triple Negative Breast Neoplasms
09/2021 - 03/2010
6Ovarian Neoplasms (Ovarian Cancer)
01/2020 - 09/2005
5Carcinoma (Carcinomatosis)
01/2020 - 01/2007
5Neoplasm Metastasis (Metastasis)
06/2019 - 11/2012
3Carcinogenesis
09/2021 - 03/2010
2Lung Neoplasms (Lung Cancer)
03/2015 - 06/2007
1Inflammatory Breast Neoplasms
09/2017
1Tetraploidy
12/2015
1Weight Loss (Weight Reduction)
02/2012
1Ovarian Epithelial Carcinoma
02/2012
1Tuberous Sclerosis (Bourneville's Disease)
01/2012
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2011
1Infections
01/2007

Drug/Important Bio-Agent (IBA)

6ErbB Receptors (EGF Receptor)IBA
11/2012 - 06/2007
5Phosphotransferases (Kinase)IBA
01/2017 - 08/2007
5Proteins (Proteins, Gene)FDA Link
01/2012 - 11/2002
4Tyrosine Kinase InhibitorsIBA
03/2015 - 06/2007
4Erlotinib Hydrochloride (CP 358,774)FDA Link
02/2012 - 06/2007
3Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
12/2015 - 01/2012
3PhosphoproteinsIBA
01/2015 - 12/2010
2Pharmaceutical PreparationsIBA
01/2021 - 12/2015
2GemcitabineFDA Link
01/2021 - 01/2011
2Protein Isoforms (Isoforms)IBA
01/2020 - 07/2014
2Progesterone Receptors (Progesterone Receptor)IBA
06/2019 - 12/2015
2AgarIBA
06/2019 - 03/2010
2Estrogen ReceptorsIBA
06/2019 - 12/2015
2Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
01/2019 - 03/2010
2Mitogen-Activated Protein KinasesIBA
01/2019 - 01/2012
2AZD 6244IBA
12/2015 - 02/2012
2Trastuzumab (Herceptin)FDA Link
06/2015 - 07/2014
2Liposomes (Liposome)IBA
01/2015 - 11/2002
2Lapatinib (GW572016)FDA Link
07/2014 - 07/2008
2Tyrosine (L-Tyrosine)FDA Link
01/2011 - 08/2007
2DNA (Deoxyribonucleic Acid)IBA
03/2010 - 11/2002
1Interleukin-8 (Interleukin 8)IBA
09/2021
1birinapantIBA
01/2021
1Early Growth Response Protein 1IBA
01/2020
1FilaminsIBA
01/2020
1Cisplatin (Platino)FDA LinkGeneric
01/2020
1Annexin A5IBA
06/2019
1human ERBB2 proteinIBA
06/2019
1Serotonin (5 Hydroxytryptamine)IBA
10/2017
1Serotonin Receptor Agonists (Serotonin Receptor Agonist)IBA
10/2017
15-nonyloxytryptamineIBA
10/2017
1Tryptamines (Triptans)IBA
10/2017
1EnzymesIBA
06/2017
1GD2 gangliosideIBA
06/2017
14(2'- aminoethyl)amino- 1,8- dimethylimidazo(1,2- a)quinoxalineIBA
06/2017
1Biological ProductsIBA
01/2017
1KW-2450IBA
12/2015
1Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA
12/2015
1MicroRNAs (MicroRNA)IBA
06/2015
1Telomerase (Telomerase Reverse Transcriptase)IBA
01/2015
1Etoposide (VP 16)FDA LinkGeneric
01/2015
1Complement System Proteins (Complement)IBA
01/2015
1N- (2,3- dihydroxypropyl)- 1- ((2- fluoro- 4- iodophenyl)amino)isonicotinamideIBA
01/2015
1entinostat (MS 275)IBA
07/2014
1Indicators and Reagents (Reagents)IBA
07/2014
1Apoptosis Regulatory ProteinsIBA
07/2014
1Histone Deacetylases (Histone Deacetylase)IBA
07/2014
1Histone Deacetylase InhibitorsIBA
07/2014
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2014
1Peptides (Polypeptides)IBA
04/2014
1ProlactinIBA
04/2014
1Glucose (Dextrose)FDA LinkGeneric
06/2013
1Paclitaxel (Taxol)FDA LinkGeneric
06/2013
1Cyclin-Dependent Kinases (cdk Proteins)IBA
09/2011
1CyclinsIBA
09/2011
1Trypan BlueFDA Link
03/2010
1Bromodeoxyuridine (BrdU)IBA
03/2010
1Hormones (Hormone)IBA
03/2010
1Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
07/2008
1Cyclin-Dependent Kinase 2IBA
08/2007
1Gefitinib (Iressa)FDA Link
08/2007
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
06/2007
1TensinsIBA
06/2007
1PlatinumIBA
01/2007
1Caspase 9IBA
01/2007
1Tumor Protein p73IBA
01/2007
1Celecoxib (Celebrex)FDA Link
01/2007
1Antisense OligonucleotidesIBA
09/2005
1Protamines (Protamine Sulfate)FDA Link
11/2002
1LipidsIBA
11/2002

Therapy/Procedure

12Therapeutics
09/2021 - 07/2008
7Drug Therapy (Chemotherapy)
01/2021 - 01/2007